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The main resident stem cell of skeletal muscle is the satellite cell. The Zammit group’s core research is focused on understanding how satellite cell function is regulated. The group is interested in satellite cell function in normal, aged and diseased muscle. They are currently examining the role of signaling pathways, including sphingosine-1-phosphate and BMP, in the control of satellite cell self-renewal and differentiation. The Zammit laboratory also studies how satellite cell dysfunction can contribute to disease progression in muscular dystrophies and certain cancers.