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Megarole for microRNA in muscle disease


Details
Publication Date: 
03/11/2010
Authors: 
Crist, CG, Buckingham, M
Citation: 
Cell Metab. ;12(5):425-6.
DOI: 
10.1016/j.cmet.2010.10.007
Abstract

Deregulation of microRNAs in dystrophic muscle highlights their importance in muscle homeostasis. A recent study in Cell Metabolism (Cacchiarelli et al., 2010) shows that the presence of functional dystrophin is required for NO-dependent nitrosylation of the HDAC2 repressor and subsequent activation of a group of microRNAs required for muscle function.