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Moving to tolerance: clinical application of T regulatory cells


Details
Publication Date: 
28/05/2011
Authors: 
McMurchy AN, Bushell A, Levings MK, Wood KJ.
Citation: 
Semin Immunol. 2011 Aug;23(4):304-13. Epub 2011 May 28.
DOI: 
10.1016/j.smim.2011.04.001
Abstract

Decreasing the incidence of chronic rejection and reducing the need for life-long immunosuppression remain important goals in clinical transplantation. In this article, we will review how regulatory T cells (Treg) came to be recognized as an attractive way to prevent or treat allograft rejection, the ways in which Treg can be manipulated or expanded in vivo, and the potential of in vitro expanded/generated Treg for cellular therapy. We will describe the first regulatory T cell therapies that have been or are in the process of being conducted in the clinic as well as the safety concerns of such therapies and how outcomes may be measured.