You are hereOur Research / Publications / Pericytes resident in post-natal skeletal muscle differentiate into muscle fibers and enter the satellite cell pool

Pericytes resident in post-natal skeletal muscle differentiate into muscle fibers and enter the satellite cell pool


Details
Publication Date: 
11/10/2011
Authors: 
Dellavalle A, Maroli G, Covarello D, Azzoni E, Innocenzi A, Perani L, Antonini S, Sambasivan R, Brunelli S, Tajbakhsh S, Cossu G.
Citation: 
Nat Commun. 2011 Oct 11;2:499. doi: 10.1038/ncomms1508.
DOI: 
10.1038/ncomms1508.
Abstract
Skeletal muscle fibres form by fusion of mesoderm progenitors called myoblasts.
      After birth, muscle fibres do not increase in number but continue to grow in size
      because of fusion of satellite cells, the postnatal myogenic cells, responsible
      for muscle growth and regeneration. Numerous studies suggest that, on
      transplantation, non-myogenic cells also may contribute to muscle regeneration.
      However, there is currently no evidence that such a contribution represents a
      natural developmental option of these non-myogenic cells, rather than a
      consequence of experimental manipulation resulting in cell fusion. Here we show
      that pericytes, transgenically labelled with an inducible Alkaline Phosphatase
      CreERT2, but not endothelial cells, fuse with developing myofibres and enter the 
      satellite cell compartment during unperturbed postnatal development. This
      contribution increases significantly during acute injury or in chronically
      regenerating dystrophic muscle. These data show that pericytes, resident in small
      vessels of skeletal muscle, contribute to its growth and regeneration during
      postnatal life.