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Vision from the right stem


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Publication Date: 
11/11/2010
Authors: 
Pellegrini G, Rama P, De Luca M
Citation: 
Trends Mol Med. 2010 Nov 11. [Epub ahead of print]
DOI: 
10.1016/j.molmed.2010.10.003
Abstract
Cultures of limbal cells are a safe and effective treatment for the destruction
of the human cornea owing to chemical burns. The essential feature of the graft
is the presence of an adequate number of stem cells, which can be determined by
the expression of the p63 transcription factor. Here, we will discuss the general
principles defining the rigorous criteria for graftable limbal cultures in light 
of their clinical performances. Such criteria might prove relevant to the future 
therapeutic use of any cultured cell type.